Stapled peptide inhibitors of nemo as potential anti-inflammatory and anti-cancer drugs

A peptide, comprising an amino sequence (I) which is at least 60% identical to the amino acid sequence SEQ ID NO:

• 1, and further comprising at least one macrocycle-forming linker connecting a first amino acid to a second amino acid of said sequence (I),
• wherein the sequence (I) consists of:
• (SEQ ID NO:
• 2)
• LKX1QAX2X3YK X4RFX5X6X7R X8ARX9K,
• in which:
• X1 is A;
• X2 is a cross-linked amino acid;
• X3 is I;
• X4 is A;
• X5 is a cross-linked amino acid;
• X6 is A;
• X7 is E;
• X8 is H or Q;
• and
• X9 is E;
• providing that X2 and X5 are cross-linked by the macrocycle-forming linker.