Crystalline 19-nor C3,3-disubstituted C21-n-pyrazolyl steroid
AssigneeSage Therapeutics, Inc.
InventorsPaul Steven Watson, Bret Berner, John Gregory Reid, Jian Wang, James J. Doherty, Stephen Jay Kanes
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Abstract
This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.
Claims19
A method for treating a CNS-related disorder, wherein the CNS-related disorder is a mood disorder, a psychotic disorder, an anxiety disorder, tremor, or tinnitus, in a subject in need thereof, comprising administering to the subject an effective amount of a crystalline solid Form C of Compound 1:
- wherein the crystalline solid Form C of Compound 1 has an XRPD pattern comprising peaks between and including 9.7 to 10.1 degrees in 2θ, between and including 11.6 to 12.0 degrees in 2θ, between and including 13.2 to 13.6 degrees in 2θ, between and including 14.2 to 14.6 degrees in 2θ, between and including 14.6 to 15.0 degrees in 2θ, between and including 16.8 to 17.2 degrees in 2θ, between and including 20.5 to 20.9 degrees in 2θ, between and including 21.3 to 21.7 degrees in 2θ, between and including 21.4 to 21.8 degrees in 2θ, and between and including 22.4 to 22.8 degrees in 2θ.
A method for treating a CNS-related disorder, wherein the CNS-related disorder is a mood disorder, a psychotic disorder, an anxiety disorder, tremor, or tinnitus, in a subject in need thereof, comprising administering to the subject an effective amount of a crystalline solid Form C of Compound 1:
- wherein the crystalline solid Form C of Compound 1 has an XRPD pattern comprising peaks between and including 9.7 to 10.1 degrees in 2θ, between and including 14.6 to 15.0 degrees in 2θ, between and including 16.8 to 17.2 degrees in 2θ, between and including 20.5 to 20.9 degrees in 2θ, and between and including 21.3 to 21.7 degrees in 2θ.
A method for treating a CNS-related disorder, wherein the CNS-related disorder is a mood disorder, a psychotic disorder, an anxiety disorder, tremor, or tinnitus, in a subject in need thereof, comprising administering to the subject an effective amount of a crystalline solid Form C of Compound 1:
- wherein the crystalline solid Form C of Compound 1 has an XRPD pattern comprising peaks at 9.9 degrees in 2θ, 14.8 degrees in 2θ, 17.0 degrees in 2θ, 20.7 degrees in 2θ, and 21.5 degrees in 2θ.
Dependencies are inferred from the claim text.