1,3-acetonedicarboxylate-derived amphipathic compounds and uses thereof

A method of preparing a compound represented by Formula 1, the method comprising:

• 1) allowing an alkyl halide to react with a compound of Formula 3, followed by reducing the reaction product to prepare a triol compound of Formula 4 (Step 1);
• and
• 2) introducing a saccharide to which a protecting group is attached into the compound of Formula 4 through a glycosylation reaction, followed by performing a deprotection reaction (Step 2):
• wherein:
• R1 or R2 is a substituted or unsubstituted C1-C15 alkyl group;
• and
• X1 to X3 are each independently a saccharide.

A method of preparing a compound represented by Formula 2, the method comprising:

• 1) subjecting a compound of Formula 3 to an enolization reaction to prepare a compound of Formula 5 (Step 1);
• 2) allowing the compound of Formula 5 to react with an alkyl iodide to prepare a dialkylated compound of Formula 6 (Step 2);
• 3) isomerizing the compound of Formula 6 into a keto form to prepare a compound of Formula 7 (Step 3);
• 4) reducing the compound of Formula 7 to prepare a triol compound of Formula 8 (Step 4);
• and
• 5) introducing a saccharide to which a protecting group is attached into the compound of Formula 8 through a glycosylation reaction, followed by performing a deprotection reaction (Step 5):
• wherein:
• R1 or R2 is a substituted or unsubstituted C1-C15 alkyl group;
• and
• X1 to X3 are each independently a saccharide.