Functionalized n-acetylgalactosamine analogs

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein
• each of R1, R2, and R3 is independently hydrogen, benzyl, or —C(═O)R8;
• R4 is —C(═O)C1-6 alkyl or —C(═O)C1-6 haloalkyl;
• R5 is a hydroxy protecting group;
• R6 is hydrogen, a phosphoramidite moiety, —C(═O)CH2CH2C(═O)R6A, or —P(OR6B)NR6CR6D;
• Y1 is NR7 or *NR7C(═O), the asterisk * indicates that Y1 is connected to L3 through the nitrogen atom of Y1, provided that when Y1 is *NR7C(═O), then L4 is absent;
• Z1 is C(RZ), P(═S), or P(═O), wherein RZ is hydrogen or unsubstituted C1-6 alkyl;
• each of L1, L2, and L3 is independently a bond, —C(═O)—, —C(═S)—, —S(═O)2—, —C(═O)NR9—, —C(═S)NR9—, —C(═O)O—, —C(═S)O—, —NR9C(═O)NR9—, —NR9C(═S)NR9—, —OP(═O)(OH)O—, —OP(═S)(OH)O—, —O—, —S—, —NR9—, optionally substituted C1-10 alkylene, optionally substituted C6-10 arylene, optionally substituted C3-10 cycloalkylene, optionally substituted 5-10 membered hetetroarylene, optionally substituted 5 to 10 membered heterocyclylene, or optionally substituted 2 to 15 membered heteroalkylene wherein one or more carbon atoms are replaced with C(═O), O, S or N, provided that at least one of L1, L2, and L3 is not a bond;
• L4 is optionally substituted C1-8 alkylene;
• each of R7 and R9 is independently hydrogen, unsubstituted C1-6 alkyl, substituted C1-6 alkyl, or an amino protecting group;
• each R8 is independently C1-6 alkyl, C1-6 haloalkyl, or optionally substituted phenyl;
• R6A is —OH, —OR10 or —NR11R12;
• each of R6B, R6C and R6D is independently H, C1-6 haloalkyl, or unsubstituted or substituted C1-6 alkyl;
• R10 is unsubstituted or substituted C1-6 alkyl, or a hydroxy protecting group;
• each of R11 and R12 is independently H, unsubstituted or substituted C1-6 alkyl, or an amino protecting group;
• and
• each of m and n is independently 0, 1, 2 or 3, provided that
• m and n cannot both be 0;
• and
• when -L1-L2-L3- comprise one or more C(═O), Y1 is NR7, Z1 is C(RZ), and m+n=1;
• then RZ is unsubstituted C1-6 alkyl.