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US 11,884,683 B2Granted
Tricyclic heterocycle compounds useful as HIV integrase inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsTao Yu, Alan Whitehead, Yili Chen, Chunrui Sun, Zhiyong Hu, Kake Zhao, Ronald M. Kim, John A. McCauley
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Abstract
The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
Claims17
A compound of the formula:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- each occurrence of R1 is independently halo or C1-3 alkyl, wherein said alkyl groups are optionally substituted with one to three halo;
- R2 is hydrogen, methyl or ethyl;
- R3 is hydrogen, methyl or ethyl;
- R4 is hydrogen, methyl or ethyl;
- R5 is hydrogen, C1-3 alkyl, (C1-3 alkyl)OR7 or phenyl;
- or R4 and R5 can be taken together with the carbon atom to which they are attached to form a 5- or 6-membered heterocyclyl group;
- R6 is hydrogen, C1-6 alkyl or (C1-6 alkyl)OR7;
- or R5 and R6 can be taken together with the atoms between them to form a 6-membered heterocyclyl group;
- R7 is hydrogen or C1-3 alkyl, which is optionally substituted with one to three halo;
- n is an integer between one and three.
9 more elements
Dependencies are inferred from the claim text.