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US 11,884,681 B2Granted
3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives as TRPA1 inhibitors
AssigneeBoehringer Ingelheim International GmbH
InventorsMartin Thomas Fleck, Florian Paul Christian Binder
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Abstract
The present disclosure provides certain 3H,4H,5H,6H,7H-pyrimido[4,5-b][1,4]oxazine-4,6-dione derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
Claims9
A compound according to formula (I)
- wherein
- A is selected from the group consisting of phenyl, thiophenyl, benzofuranyl and benzothiophenyl, and wherein A is unsubstituted or substituted with one or two members of the group R1 selected from the group consisting of halogen and C1-4-alkyl;
- or a salt thereof.
Dependencies are inferred from the claim text.