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US 11,884,674 B2Granted
Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
AssigneeBeiGene Switzerland GmbH
InventorsZhiwei Wang, Yunhang Guo, Gongyin Shi, Lai Wang
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Abstract
The present invention relates to a crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide for inhibiting Btk, methods of preparation thereof and pharmaceutical compositions, and use of the crystalline form above in the treatment of a disease, or in the manufacturing of a medicament for the treatment of a disease.
Claims28
A method for treating a B-cell proliferative disease in a subject, comprising administering to the subject in need thereof Compound 1,
- wherein the B-cell proliferative disease is selected from a group consisting of chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, Waldenström's macroglobulinemia, marginal zone lymphoma, and follicular lymphoma;
- and
- Compound 1 is administrated at a dose of 160 mg twice a day (BID).
Dependencies are inferred from the claim text.