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US 11,884,673 B2Granted
Modulators of ion channel receptors and uses thereof
AssigneeBionomics Limited
InventorsBelinda Huff, Courtney Hollis, Hamish Toop, Nathan Kuchel, Lorna Helen Mitchell, Rajinder Singh
Life of this patent
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Abstract
Compounds useful in the modulation of ion channel activity in cells are disclosed herein. This disclosure also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.
Claims16
A compound of formula (I)
- or a salt, stereoisomer, solvate or prodrug thereof,
- wherein
- R is an optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
- R1 is H or an optionally substituted C1-C4 alkyl;
- R2, R3, R4 and R5 are independently H or a C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
- Y is selected from
- X is CH or N;
- and
- Z is F or CF3.
6 more elements
A method of manufacturing a medicament for treating pain disorders, said method comprising preparing a compound of formula (I)
- or a salt, stereoisomer, solvate or prodrug thereof,
- wherein:
- R is an optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
- R1 is H or an optionally substituted C1-C4 alkyl;
- R2, R3, R4 and R5 are independently H or a C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
- Y is selected from
- X is CH or N;
- and
- Z is F or CF3.
6 more elements
Dependencies are inferred from the claim text.