Substituted pyrrolo[2,3-c][2,7]naphthyridines as CK2 inhibitors

A compound having the formula I:

• or a pharmaceutically acceptable salt or stereoisomer thereof,
• wherein:
• R1 is H, C1-C6 alkyl, or C3-C6 cycloalkyl;
• R2 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, (CH2)2-3 NR3R4, (CH2)1-2 aryl, (CH2)1-2 heteroaryl, C(O)—(CH2)2-3NR3R4, C(O)aryl, C(O)heteroaryl, S(O)2—(CH2)2-3 NR3R4, S(O)2aryl, S(O)2heteroaryl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C3-C6 cyanocycloalkyl, aryl, or 5- or 6-membered heteroaryl;
• wherein the aryl of (CH2)1-2 aryl or the heteroaryl of (CH2)1-2 heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C(O)R3, C(O)NR3R4, C(O)OR3, NR3R4, NHC(O)R3, NHC(O)NHR3, NHC(O)OR3, NHS(O)2R3, NHS(O)2NHR3, OH, S(O)2NR3R4, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, and C3-C6 cyanocycloalkyl;
• wherein the C(O)aryl, C(O)heteroaryl, S(O)2 aryl, or S(O)2heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C(O)R3, C(O)NR3R4, C(O)OR3, NR3R4, NHC(O)R3, NHC(O)NHR3, NHC(O)OR3, NHS(O)2R3, NHS(O)2NHR3, OR3, S(O)2NR3R4, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, and C3-C6 cyanocycloalkyl;
• and
• wherein the aryl or 5- or 6-membered heteroaryl is optionally substituted with one, two, or three substituents independently selected from the group consisting of halogen, CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C(O)R3, C(O)NR3R4, C(O)OR3, NR3R4, NHC(O)R3, NHC(O)NHR3, NHC(O)OR3, NHS(O)2R3, NHS(O)2NHR3, OR3, S(O)2NR3R4, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, and C3-C6 cyanocycloalkyl;
• each R3 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, or C3-C6 cyanocycloalkyl;
• and
• each R4 is independently H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 cyanoalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, or C3-C6 cyanocycloalkyl;
• or
• any R3 and R4, taken together with the nitrogen atom to which they are attached, independently forms a nitrogen-containing heterocyclyl, wherein each nitrogen-containing heterocyclyl is optionally and independently substituted with one, two, or three substituents independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 trihaloalkyl, OH, and OC1-C6 alkyl.