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US 11,884,666 B2Granted
Azabicyclo and diazepine derivatives
AssigneeAlcon Inc.
InventorsDavid Ellis, Howard Allen Ketelson
Life of this patent
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Abstract
The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.
Claims13
A compound or a pharmaceutically acceptable salt thereof, wherein the compound is presented by formula (II):
- wherein
- Me=CH3;
- W=N or CH;
- X=—O—Y—Z, —S—Y—Z, or —NR5—Y—Z;
- R5=H or C1-C20 straight or branched alkyl groups, C1-C10 straight or branched haloalkyl groups;
- Y is a bivalent radical having the following meaning:
- a) straight or branched C1-C20 alkyl, being optionally substituted with one or more of the substituents selected from the group consisting of:
- halogen atoms and hydroxyl;
- b) —C(O)(C1-C10 alkyl)- or —C(O)(CH2)nC(O)O—(C1-C10 alkyl)- or —(C1-C10 alkyl)—;
- wherein n is an integer from 0 to 20;
- R6 and R7 are independently H or C1-C10, straight or branched alkyl groups, C1-C10 straight or branched haloalkyl groups;
- and
- Z is H, —OH, C1-6 alkoxy, —COOH.
10 more elements
Dependencies are inferred from the claim text.