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US 11,884,650 B2Granted
Substituted heterocyclic compounds
AssigneeBristol-Myers Squibb Company
InventorsSteven H. Spergel, Ryan M. Moslin, Michael Edward Mertzman
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Abstract
There are disclosed compounds of the following formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.
Claims6
A compound of formula I
- or a stereoisomer or pharmaceutically acceptable salt thereof,
- wherein
- X is —N— or —CH—;
- R1 is —C(O)R1a;
- R1a is C3-6 cycloalkyl;
- R2 is C1-6 alkoxy;
- R3 is C1-6 alkyl or C3-6 cycloalkyl.
4 more elements
A compound or a pharmaceutically acceptable salt thereof, selected from
- N-(4-((3-methoxy-4-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
- N-(4-((3-methoxy-4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
- N-(4-((2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
- N-(4-((4-fluoro-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
- N-(4-((3-fluoro-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide, and
- N-(4-((3-methyl-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide.
3 more elements
Dependencies are inferred from the claim text.