Substituted phenyl quinolin-l-ium bromide derivative as anti-tubercular agents
AssigneeKing Faisal University
InventorsKatharigatta N. Venugopala, Pran Kishore Deb, Melendran Pillay, Sandeep Chandrashekharappa, Mohamed A. Morsy, Bandar Adlhubiab, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Christophe Tratrat, Sheena Shashikanth
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Abstract
Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are phenyl quinolin-1-ium bromide derivatives and their use as anti-tubercular agents.
Claims18
A compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R is selected from the group consisting of a C1-C6 straight or branched chain alkyl and a C1-C6 trihaloalkyl;
- and
- n is an integer from 1 to 3.
A compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R is selected from the group consisting of methyl and trifluoromethyl;
- and
- n is an integer from 1 to 3.
A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
- R is selected from the group consisting of methyl and trifluoromethyl;
- and
- n is an integer from 1 to 3.
Dependencies are inferred from the claim text.