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US 11,884,624 B2Granted
Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
AssigneeCayman Chemical Company, Incorporated
InventorsStephen Douglas Barrett, Fred Lawrence Ciske, Joseph Michael Colombo, Gregory William Endres, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Kirk M. Maxey
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Abstract
Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.
Claims3
A compound of formula (13):
- wherein:
- L1 is
- a) C3-C7alkylene, C3-C7alkenylene, or C3-C7alkynylene;
- or
- b) —(CH2)n1-G2- (CH2)p—, —(CH2)n2—C≡C-G2-, or —(CH2)n2—C(R12)═C(R12)-G2-, wherein n1 is 2, 3, 4, or 5, n2 is 1, 2, or 3, p is 0, 1, 2, or 3, and n1+p=2, 3, 4, 5, or 6;
- G2 is
- R1 is a protected carboxylic acid;
- R12, at each occurrence, is independently H or C1-C4alkyl;
- and
- R20 is H or a hydroxyl protecting group.
7 more elements
Dependencies are inferred from the claim text.