Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus

A prefilled syringe comprising:

• a syringe barrel having a lumen defined at least in part by a thermoplastic wall having an interior surface facing the lumen and an outer surface;
• a lubricity coating of SiwOxCy, in which w is 1, x is from about 0.5 to about 2.4, and y is from about 0.6 to about 3, the lubricity coating having an inner surface facing the lumen and an outer surface facing the interior surface of the thermoplastic wall, the lubricity coating having a lower frictional resistance than an uncoated surface of the thermoplastic wall;
• a fluid composition contained in the lumen, the fluid composition comprising a botulinum toxin and having a pH between 4 and 10,
• a plunger tip positioned in the lumen and being slidable along the interior surface of the wall;
• and
• a cap or needle shield at a distal end of the syringe barrel;
• wherein the shelf life of the prefilled syringe is more than six months at a storage temperature of 4° C.