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US 11,883,821 B2Granted
Fluidic device for the detection, capture, or removal of a disease material
AssigneeVanderbilt University
InventorsSinead E. Miller, Charleson S. Bell, Todd D. Giorgio, Andrew L. Cook
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Abstract
The present disclosure relates to a fluidic device to detect, capture, and/or remove disease material in a biological fluid. The present invention also relates to methods for the treatment/prevention of sepsis through the use of the claimed device.
Claims18
A method for capture of a disease material from a biological fluid,
- the method comprising:
- introducing the biological fluid into a fluidic device, wherein the fluidic device comprises at least one inlet, at least one outlet, and a multidirectional channel between the at least one inlet and the at least one outlet;
- flowing the biological fluid through the fluidic device to expose the disease material to a disease material-targeting ligand functionalized along at least a portion of an inner wall of the multidirectional channel within the fluidic device;
- capturing the disease material with the disease material-targeting ligand, thereby removing the disease material from the biological fluid;
- removing the disease material from the biological fluid to produce treated biological fluid;
- and
- returning the treated biological fluid to a patient.
4 more elements
Dependencies are inferred from the claim text.