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US 11,883,679 B2Granted
Systems and methods for ultrasound induced thrombolysis with magnetic microbubbles, optional nanodroplets, and a rotational magnetic field
AssigneeNorth Carolina State University
InventorsXiaoning Jiang, Bohua Zhang
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Abstract
The disclosure provides systems for ultrasound-induced thrombolysis with magnetic microbubbles under a rotational/alternating magnetic field, sonothrombolysis systems with magnetic microbubbles and optional nanodroplets for inducing thrombolysis under an acoustic field, and a rotational/alternating magnetic field, and methods of treating patients with blood clots using the sonothrombolysis systems of the present disclosure.
Claims24
A system comprising:
- a plurality of magnetic microbubbles (MMBs) having a gas core and a layer of superparamagnetic nanoparticles around the gas core,
- an ultrasound transducer effective to induce cavitation of the MMBs, wherein the ultrasound transducer is configured to generate an acoustic frequency of about 100 kHz to about 5 MHz, with an ultrasound duty cycle of about 0.5% to about 25%, and an input voltage of about 10Vpp to 250 Vpp, and
- a rotational magnetic field generator effective to accumulate MMBs in a target region and increase cavitation of the MMBs induced by the ultrasound transducer.
A method of treating blood clots, the method comprising:
- administering magnetic microbubbles (MMBs) intravascularly to a patient in need of treatment for a blood clot in a blood vessel, the MMBs having a gas core and a layer of superparamagnetic nanoparticles around the gas core;
- localizing the MMBs to a target clot region in the blood vessel by application of a magnetic field;
- generating a rotational magnetic field in the target clot region to retain the MMBs in the target clot region and enhance ultrasound-induced movement of the MMBs;
- and
- using an ultrasound transducer to acoustically activate the MMBs to generate movement of the MMBs within the blood vessel in the target clot region, wherein the ultrasound transducer generates an acoustic frequency of about 100 kHz to about 5 MHz, has an ultrasound duty cycle of about 0.5% to about 25%, and has an input voltage of about 10 Vpp to 250 Vpp, and wherein movement of the MMBs induced by the ultrasound is increased under the rotational magnetic field, such that the movement of the MMBs is effective to reduce the blood clot in size.
2 more elements
A kit comprising:
- an ultrasound transducer effective to induce in vivo cavitation of a plurality of magnetic microbubbles (MMBs) in a target region of a subject,
- a portable, targeted rotational magnetic field generator effective to accumulate MMBs in a target region and increase cavitation of the MMBs induced by the ultrasound transducer, and
- instructions for using the ultrasound transducer and portable, targeted rotational magnetic field generator with a composition of MMBs and optional NDs to treat a subject, wherein the instructions describe the use of the ultrasound transducer to generate an acoustic frequency of about 100 kHz to about 5 MHz, with an ultrasound duty cycle of about 0.5% to about 25%, and an input voltage of about 10 Vpp to 250 Vpp.
Dependencies are inferred from the claim text.