Systems and methods for treatment of pancreatic cancer

A method of treating pancreatic cancer comprising:

• positioning a first electrical stimulation lead on or about a posterior exterior surface of a duodenum of a patient, the first electrical stimulation lead comprising a first plurality of electrodes and a first surface contact member disposed thereon, wherein the first surface contact member is configured to pivot around the first electrical stimulation lead, and wherein the first surface contact member comprises a window configured to expose a portion of the first plurality of electrodes, wherein the window is disposed on a side of the surface contact member opposite a side of the surface contact member disposed on the posterior exterior surface of the duodenum;
• positioning a second electrical stimulation lead on or about an anterior exterior surface of the duodenum of the patient, the second electrical stimulation lead comprising a second plurality of electrodes and a second surface contact member disposed thereon, wherein the second surface contact member is configured to pivot around the second electrical stimulation lead;
• and
• generating an electrical field between at least one pair of electrodes selected from the first plurality and the second plurality disposed on the electrical stimulation lead, the electric field having frequencies within a range of between 10 kHz to 1 MHz;
• wherein the first and/or second surface contact member comprises a surface configured to contact a surface of the duodenum, wherein a surface adjacent to the duodenum of the first and/or second surface contact members comprises an electrical field blocking pad.

A medical device system comprising:

• an electric field generating circuit configured to generate one or more electric fields;
• and
• control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit;
• one or more electrodes disposed on a first stimulation lead configured to deliver the electric fields to a site of a cancerous tumor within a patient;
• one or more electrodes disposed on a second stimulation lead configured to deliver the electric fields to the site of a cancerous tumor within a patient;
• and
• plurality of surface contact members disposed along the first stimulation lead configured to pivot around the first stimulation lead, the plurality of surface contact members comprising a window configured to expose a portion of the one or more electrodes disposed on the first stimulation lead, wherein the window has a width less than a diameter of the first stimulation lead;
• wherein the first and second stimulation leads are configured to be implanted on or about a duodenum;
• wherein the control circuitry causes the electric field generating circuit to generate the one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz;
• and
• wherein the plurality of surface contact members comprise a surface configured to contact a surface of the duodenum, wherein a surface adjacent to the duodenum of the one or more surface contact members comprises a thermal shielding pad.