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US 11,883,620 B2Granted
Controlled flow drug delivery implantable device
OwnerNeil S. Daveyinventor
Life of this patent
Estimating the term…
Abstract
Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.
Claims20
A system comprising an implantable device comprising:
- A. a casing that is substantially tubular and has at least a first end and a second end opposite to the first end,
- B. a semi-permeable membrane plug at or near the first end,
- C. a first chamber, wherein one wall of the first chamber comprises the semi-permeable plug,
- D. a second chamber comprising a drug,
- E. a third chamber near the second end,
- F. a piston separating the first chamber and the second chamber,
- G. an opening for release of the drug from the implantable device into a body of a human or an animal,
- H. a sensor attached directly to the implantable device, and
- I. an energy source that produces electricity;
- wherein:
- a. the implantable device is configured to be implanted within the body of the human or the animal during delivery of the drug into the body of the human or the animal and provide, while implanted within the body of the human or the animal, the drug at a constant concentration for a certain amount of time, followed by no drug release for some time, and subsequently followed by providing the drug at the constant concentration,
- b. the first chamber is between the semi-permeable membrane plug and the piston,
- c. as liquid is drawn into the first chamber through the semi-permeable membrane plug, the implantable device is configured to build an osmotic pressure and push the piston,
- d. the second chamber is between the first chamber and the third chamber;
- and
- e. the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device by delivering the drug through the opening.
13 more elements
An implantable device comprising:
- A. a casing that is substantially tubular and has at least a first end and a second end opposite to the first end,
- B. a semi-permeable membrane plug at or near the first end,
- C. a first chamber, wherein one wall of the first chamber comprises the semi-permeable plug,
- D. a second chamber comprising a drug,
- E. a third chamber near the second end,
- F. a piston separating the first chamber and the second chamber,
- G. an opening for release of the drug from the implantable device into a body of a human or an animal,
- H. a sensor attached directly to the implantable device, wherein the sensor is configured to send a signal indicating when to stop the piston from moving within the implantable device, and
- I. an energy source that produces electricity;
- wherein:
- a. the implantable device is configured to be implanted within the body of the human or the animal during delivery of the drug into the body of the human or the animal and repeatedly provide, while implanted within the body of the human or the animal, a drug release for a certain amount of time and no drug release for some time,
- b. the first chamber is between the semi-permeable membrane plug and the piston,
- c. as liquid is drawn into the first chamber through the semi-permeable membrane plug, the implantable device is configured to build an osmotic pressure and push the piston,
- d. the second chamber is between the first chamber and the third chamber;
- and
- e. the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device by delivering the drug through the opening.
13 more elements
A system comprising an implantable device comprising:
- A. a casing that is substantially tubular and has at least a first end and a second end opposite to the first end,
- B. a semi-permeable membrane plug at or near the first end,
- C. a first chamber, wherein one wall of the first chamber comprises the semi-permeable plug,
- D. a second chamber comprising a drug,
- E. a third chamber near the second end,
- F. a piston separating the first chamber and the second chamber,
- G. an opening for release of the drug from the implantable device into a body of a human or an animal,
- H. an energy source that produces electricity,
- G. a magnet;
- wherein:
- a. the implantable device is configured to be implanted within the body of the human or the animal during delivery of the drug into the body of the human or the animal,
- b. the first chamber is between the semi-permeable membrane plug and the piston,
- c. as liquid is drawn into the first chamber through the semi-permeable membrane plug, the implantable device is configured to build an osmotic pressure and push the piston,
- d. the second chamber is between the first chamber and the third chamber;
- and
- e. the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device by delivering the drug through the opening,
- f. the implantable device is configured to provide the drug at a constant concentration for a certain amount of time, followed by no drug release for some time, and subsequently followed by providing the drug at the constant concentration;
- and
- g. the implantable device is configured to lessen or stop the drug release by the magnet.
16 more elements
Dependencies are inferred from the claim text.