Renal failure therapy system and method of cleaning using citric acid

A cleaning method for a renal failure therapy machine, the method comprising:

• filling a dialysis fluid circuit of the renal failure therapy machine with purified water and a physiological cleaning, disinfecting, and/or decalcifying substance to form a mixture;
• circulating the mixture to at least one of clean, disinfect or decalcify the dialysis fluid circuit;
• draining a first portion of the mixture from the dialysis fluid circuit, thereby leaving a second portion of the mixture within the dialysis fluid circuit;
• priming the dialysis fluid circuit by filling the dialysis fluid circuit with second purified water to dilute the second portion of the mixture remaining in the dialysis fluid circuit, wherein the second purified water causes at least some of the second portion of the mixture remaining in the dialysis fluid circuit to drain;
• adding a concentrate or concentrates to the second purified water in the dialysis fluid circuit to form a dialysis fluid for a subsequent treatment;
• and
• flushing to drain part of the dialysis fluid, thereby ridding the dialysis fluid circuit of any remaining second portion of the mixture.