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AssigneeThe Secant Group, LLC
InventorsStephanie Reed, Carissa Smoot, Dennis Shull, Todd Crumbling, John D'Ottavio, Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Jared Ely
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A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.
A composition comprising poly(glycerol sebacate) urethane, wherein the poly(glycerol sebacate) urethane is formed from a poly(glycerol sebacate) resin reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric ratio in the range of 1:0.25 to 1:1.25.
A composition comprising poly(glycerol sebacate) urethane, wherein the poly(glycerol sebacate) urethane is formed from a poly(glycerol sebacate) resin having a polydispersity index in the range of 8 to less than 12.
A process of forming a poly(glycerol sebacate) urethane, the process comprising:
A composition comprising poly(glycerol sebacate) urethane and an active pharmaceutical ingredient mixed with the poly(glycerol sebacate) urethane, wherein the poly(glycerol sebacate) urethane is formed from a poly(glycerol sebacate) resin reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric ratio in the range of 1:0.25 to 1:5 and the active pharmaceutical ingredient mixed with the poly(glycerol sebacate) urethane is at least 40% w/w of the composition.
A composition comprising poly(glycerol sebacate) urethane and at least one additive mixed with the poly(glycerol sebacate) urethane, wherein the poly(glycerol sebacate) urethane is formed from a poly(glycerol sebacate) resin reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric ratio in the range of 1:0.25 to 1:5, the at least one additive is at least 40% w/w of the composition, and the at least one additive is selected from the group consisting of an active pharmaceutical ingredient, a filler, and a combination thereof.
Dependencies are inferred from the claim text.