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US 11,883,532 B2Granted
Pharmaceutical compositions for parenteral administration comprising ibuprofen and a phosphate buffer
AssigneeFresenius Kabi Austria GmbH
InventorsPatricia Preissegger, Eva Trotscha
Life of this patent
Estimating the term…
Abstract
The invention relates to pharmaceutical compositions for parenteral administration comprising a) Ibuprofen or a pharmaceutically acceptable salt thereof, and b) a phosphate buffer.
Claims19
A ready-to-use pharmaceutical composition for parenteral administration comprising
- a) 15-25 mmol/L of Ibuprofen or a pharmaceutically acceptable salt thereof, and
- b) a phosphate buffer,
- wherein the phosphate buffer and Ibuprofen are present in a molar ratio of 0.3:1 to 0.4:1, the composition has a pH of 6.5 to 8.2, and the composition is sterile and has a storage stability of at least 12 months at 25° C.
A ready-to-use pharmaceutical composition for parenteral administration comprising
- a) 2-6 g/L of Ibuprofen or a pharmaceutically acceptable salt thereof, and
- b) a phosphate buffer,
- wherein the phosphate buffer and Ibuprofen are present in a molar ratio of 0.3:1 to 0.4:1 the composition has a pH of 6.5 to 8.2, and the composition is sterile and has a storage stability of at least 12 months at 25° C.
A ready-to-use pharmaceutical composition for parenteral administration in a plastic container comprising
- a) 15-25 mmol/L of Ibuprofen or a pharmaceutically acceptable salt thereof, and
- b) a phosphate buffer,
- wherein the phosphate buffer and Ibuprofen are present in a molar ratio of 0.3:1 to 0.4:1 the composition has a pH of 6.5 to 8.2, and the composition is sterile and has a storage stability of at least 12 months at 25° C.
Dependencies are inferred from the claim text.