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US 11,883,529 B2Granted
Methods of administering anti-epilepsy agents and transport inhibitors to a subject
AssigneeMedtronic, Inc.
InventorBrian A. Duclos
Life of this patent
Estimating the term…
Abstract
Broad cerebrospinal fluid (CSF) distribution of an agent is achievable by delivering the agent in a liquid formulation to the CSF at flow rates less than 500 microliters per hour, such as between about 2 microliters per hour and about 100 microliters per hour.
Claims20
A method for affecting epilepsy in a subject, the method comprising:
- administering a liquid formulation comprising an antiepileptic compound to a cerebrospinal fluid (CSF)-containing intrathecal space of the subject;
- and
- administering a liquid formulation comprising a multidrug resistance protein (MRP) inhibitor compound to an CSF-containing intrathecal space of the subject.
(CurrentlyAmended) A method for affecting epilepsy in a subject, the method comprising:
- administering a liquid formulation comprising valproic acid to an CSF-containing intrathecal space of the subject;
- and
- administering a liquid formulation comprising a multidrug resistance protein (MRP) inhibitor compound to cerebrospinal fluid (CSF)-containing intrathecal space of the subject.
Dependencies are inferred from the claim text.