Thickening silica as fluoride carrier for tailored delivery and slow release
AssigneeGABA International Holding GmbH
InventorsAlan Ceresa, Michael Neumann, Madeleine Manns, Nathalie Coq-Bernard, Andre Brunella, Marian Holerca, Thomas Schollbach
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Abstract
Disclosed are oral care compositions comprising a thickening silica and a fluoride ion source, wherein fluoride is absorbed on the thickening silica and wherein the pH of the composition is below 5.5, as well as to methods of using these compositions. The thickening silica may have a particle size distribution (D95) less than or equal to 7 μm and a BET surface area of greater than or equal to 150 m2/g.
Claims16
An oral care composition comprising an orally acceptable vehicle, a thickening silica and a fluoride ion source, wherein fluoride is absorbed on the thickening silica, wherein the thickening silica has a particle size distribution (D95) less than or equal to 7 μm and a BET surface area of greater than or equal to 150 m2/g, and wherein the pH of the composition is below 5.5;
- wherein the thickening silica loaded with fluoride is made by mixing the thickening silica and the fluoride ion source in an aqueous solution at a pH below 5.5;
- wherein the fluoride ion source is selected from sodium fluoride, stannous fluoride, potassium fluoride, sodium monofluorophosphate, amine fluoride, ammonium fluoride, and a combination thereof;
- and
- wherein the release of fluoride plateaus at approximately 400 seconds when measured at 24° C.
Dependencies are inferred from the claim text.