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US 11,883,507 B2Granted
Expression cassette with a SynP160 promoter
AssigneeFriedrich Miescher Institute for Biomedical Research
InventorsDominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
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Abstract
The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
Claims17
An isolated expression cassette comprising:
- a nucleic acid sequence encoding a protein;
- and a promoter of at least 300 base pairs and having at least 80% identity to the sequence of SEQ ID NO:1, wherein the promoter is heterologous to the nucleic acid sequence encoding a protein and is capable of driving functional expression of the protein in a cell.
Dependencies are inferred from the claim text.