Anticancer drug-containing plant virus particles
AssigneesCase Western Reserve University, Massachusetts Institute of Technology
InventorsNicole F. Steinmetz, Stephen J. Lippard, Anna Czapar, Yaorong Zheng
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Abstract
Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
Claims12
An anticancer virus particle, comprising a tobacco mosaic virus particle and a cationic platinum-based anticancer agent and any carrier for the agent are non-covalently encapsulated within an interior channel of the tobacco mosaic virus particle.
A method of treating cancer in a subject identified as having cancer by administering to the subject a therapeutically effective amount of an anticancer virus particle, comprising a tobacco mosaic virus particle and a cationic platinum-based anticancer agent and any carrier for the agent are non-covalently encapsulated within an interior channel of the tobacco mosaic virus particle.
Dependencies are inferred from the claim text.