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US 11,883,503 B2Granted
Methods and compositions for cancer treatment
AssigneeDingfu Biotarget Co., Ltd.
InventorsTing Xu, Yan Luan, Shilong Fu, Songbing Qin, Jian Ding, Kai Fu
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Abstract
Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.
Claims5
A composition comprising an immunoconjugate and a cytotoxic agent, wherein:
- said immunoconjugate comprises a first member and a second member different from said first member, wherein said first member comprises a first Fc subunit, and said second member comprises two interleukins fused to a second Fc subunit, and said first Fc subunit associates with said second Fc subunit to form a heterodimer;
- said two interleukins are fused to an amino-terminal amino acid of said second Fc subunit;
- wherein said two interleukins are two copies of IL10;
- wherein the amino acid sequence of a light chain comprised in the first member is SEQ ID NO:
- 37, and the amino acid sequence of a heavy chain comprised in the first member is SEQ ID NO:
- 39;
- wherein said cytotoxic agent comprises a radiation agent that emits X-ray radiation and/or electron beam radiation, said cytotoxic therapy comprises at least one dose of a radiation therapy at a dosage of Gy,
- or,
- wherein said cytotoxic agent is capable of inducing immunogenic cell death comprising oxaliplatin.
6 more elements
A method of treating cancer in a subject in need thereof, comprising administrating an immunoconjugate in combination with a cytotoxic therapy,
- wherein said immunoconjugate comprises a first member and a second member different from said first member, wherein said first member comprises a first Fc subunit, and said second member comprises two interleukins fused to a second Fc subunit, and said first Fc subunit associates with said second Fc subunit to form a heterodimer;
- said two interleukins are fused to an amino-terminal amino acid of said second Fc subunit;
- wherein said two interleukins are two copies of IL10;
- wherein the amino acid sequence of a light chain comprised in the first member is SEQ ID NO:
- 37, and the amino acid sequence of a heavy chain comprised in the first member is SEQ ID NO:
- 39;
- and the amino acid sequence of the second member is SEQ ID NO:
- 50;
- wherein said cytotoxic therapy comprises X-ray radiation and/or electron beam radiation, said cytotoxic therapy comprises at least one dose of a radiation therapy at a dosage of 10 Gy.
6 more elements
Dependencies are inferred from the claim text.