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US 11,883,498 B2Granted
Luteinizing hormone-releasing hormone receptor (LHRH-R) conjugates and uses thereof
AssigneePurdue Research Foundation
InventorsPhilip Stewart Low, Jyoti Roy
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Abstract
The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.
Claims19
A conjugate of the formula B-L-A, wherein B is an LHRH-R binding antagonist of the formula
- wherein
- each R1 is independently halogen, C1-C6 alkyl or —OC1-C6 alkyl;
- each R2 is independently H, C1-C6 alkyl or C3-C6 cycloalkyl;
- R3 is C1-C6 alkyl, C3-C6 cycloalkyl, C6-C10 aryl or C1-C6 alkyl-(C6-C10 aryl);
- R4 is C1-C6 alkyl;
- each R5 is independently selected from the group consisting of halogen, C1-C6 alkyl, —OC1-C6 alkyl, —SC1-C6 alkyl and —OC6-C10 aryl;
- X and Y are each independently N, CH or CR1;
- provided that when X is N, Y is CH or CR1, and when Y is N, X is CH or CR1;
- m is an integer from 0 to 4;
- n is an integer from 0 to 3;
- and
- * represents a covalent bond to L;
- L is a linker;
- and
- A is an imaging agent;
- or a pharmaceutically acceptable salt thereof.
13 more elements
Dependencies are inferred from the claim text.