Mucosal adjuvants and delivery systems
AssigneeBoard of Trustees of the University of Arkansas
InventorsBilly M. Hargis, Neil R. Pumford, Marion Morgan, Srichaitanya Shivaramaiah, Guillermo Tellez-Isaias, Amanda Wolfenden
Life of this patent
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Abstract
Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.
Claims17
A method of enhancing the immune response to a vaccine in a mammalian subject or a poultry subject comprising administering to said subject an effective amount of an adjuvant composition comprising a carbohydrate linked to chitosan to form a Schiff base, wherein the carbohydrate is an open ring mannose moiety and an effective amount of a vaccine composition comprising an antigen, wherein the difference in administration time for the administration of the adjuvant composition and the administration of the vaccine composition is between 1 hour and 25 days.
Dependencies are inferred from the claim text.