Vaccine for use in the prophylaxis and/or treatment of a disease
AssigneeInprother Aps
InventorsPeter Holst, Christian Thirion, Lasse Neukirch
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Abstract
The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
Claims20
A nucleic acid molecule, wherein the nucleic acid molecule encodes an endogenous retrovirus (ERV) envelope protein or an immunogenic part thereof, wherein the ERV envelope protein or the immunogenic part thereof comprises a mutated immunosuppressive domain (ISD), wherein the mutated ISD comprises the peptide sequence NSQSSIDQKLANAINDLRQT (SEQ ID No. 50) or LQNRRGLDLLFLKRGGL (SEQ ID No. 8).
Dependencies are inferred from the claim text.