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US 11,883,476 B2Granted
Canine lyme disease vaccine
AssigneeIntervet Inc.
InventorsRhonda LaFleur, Jennifer C. Dant, Mark A. Mogler, Steven M. Callister, Zhichang Xu
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Abstract
The present invention provides a vaccine for canine Lyme disease and methods of making and using the vaccine alone, or in combinations with other protective agents.
Claims17
An immunogenic composition comprising two or more alphavirus RNA replicon particles each individually encoding one or more Borrelia burgdorferi antigens;
- wherein one alphavirus RNA replicon particle encodes a Borrelia burgdorferi outer surface protein A (OspA), wherein the OspA consists of the amino acid sequence of SEQ ID NO:
- 2,
- and wherein another alphavirus RNA replicon particle encodes a Borrelia burgdorferi outer surface protein C (OspC), wherein the OspC consists of the amino acid sequence of SEQ ID NO:
- 4;
- wherein both OspA-borreliacidal and OspC-borreliacidal antibodies are induced in a canine when said canine is immunized with said immunogenic composition.
2 more elements
An immunogenic composition comprising an alphavirus RNA replicon particle that encodes two or more Borrelia burgdorferi antigens;
- wherein at least one Borrelia burgdorferi antigen is an outer surface protein A (OspA) and wherein at least one other Borrelia burgdorferi antigen is an outer surface protein C (OspC), wherein at least one OspA comprises the amino acid sequence of SEQ ID NO:
- 2, and at least one OspC, comprises the amino acid sequence of SEQ ID NO:
- 4;
- and wherein both OspA-borreliacidal and OspC-borreliacidal antibodies are induced in a canine when said canine is immunized with said immunogenic composition.
1 more element
Dependencies are inferred from the claim text.