Extracellular vesicles and methods of using
AssigneeNUtech Ventures
InventorJanos Zempleni
Life of this patent
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Abstract
The present disclosure relates to materials and methods for extracellular vesicle (e.g., exosome)-mediated delivery of cargo (e.g., endogenous and/or exogenous) to non-bovine mammalian (e.g., human) cells. For example, exosomes isolated from bovine milk for delivering cargo to non-bovine mammalian (e.g., human) cells are provided.
Claims29
A milk exosome comprising:
- a biological membrane surrounding a lumen, wherein the biological membrane comprises one or more glycoprotein(s) comprising galactose,
- wherein the biological membrane is modified such that it has an increased number of the one or more glycoprotein(s) comprising galactose as compared with the natural biological membrane of the milk exosome.
A method of altering the uptake of a milk exosome into a mammalian cell or tissue, the milk exosome having a biological membrane comprising one or more glycoprotein(s) comprising galactose, comprising modifying the biological membrane of the exosome such that is has an increased number of the one or more glycoprotein(s) comprising galactose as compared with the natural biological membrane of the milk exosome.
A method of targeting a milk exosome to a selected mammalian cell or tissue, the milk exosome having a biological membrane comprising one or more glycoprotein(s) comprising galactose, comprising modifying the biological membrane of the milk exosome such that it has an increased number of the one or more glycoprotein(s) comprising galactose as compared with the natural biological membrane of the milk exosome.
Dependencies are inferred from the claim text.