Chimeric antigen receptor comprising anti-mesothelin scFv, and use thereof
AssigneeCellengene Inc
InventorsJae Hyung An, Na Kyung Han
Life of this patent
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Abstract
Provided is an anti-mesothelin chimeric antigen receptor that specifically binds to mesothelin. The anti-mesothelin chimeric antigen receptor according to an aspect exhibits a specific binding ability for mesothelin, and thus, may be useful for preventing or treating cancer in which mesothelin is overexpressed.
Claims16
An anti-mesothelin antibody or an antigen-binding fragment thereof, comprising:
- a heavy chain variable region comprising a heavy chain CDR1 comprising an amino acid sequence consisting of SEQ ID NO:
- 1;
- a heavy chain CDR2 comprising an amino acid sequence consisting of SEQ ID NO:
- 2;
- and a heavy chain CDR3 comprising an amino acid sequence consisting of SEQ ID NO:
- 3;
- and
- a light chain variable region comprising a light chain CDR1 comprising an amino acid sequence consisting of SEQ ID NO:
- 4;
- light chain CDR2 comprising an amino acid sequence consisting of SEQ ID NO:
- 5;
- and a light chain CDR3 comprising an amino acid sequence consisting of SEQ ID NO:
- 6.
A chimeric antigen receptor comprising an antigen-binding domain, a hinge domain, a transmembrane domain, and an intracellular signaling domain, wherein the antigen-binding domain is an anti-mesothelin antibody or an antigen-binding fragment thereof, comprising:
- a heavy chain variable region comprising a heavy chain CDR1 comprising an amino acid sequence consisting of SEQ ID NO:
- 1;
- a heavy chain CDR2 comprising an amino acid sequence consisting of SEQ ID NO:
- 2;
- and a heavy chain CDR3 comprising an amino acid sequence consisting of SEQ ID NO:
- 3;
- and
- a light chain variable region comprising a light chain CDR1 comprising an amino acid sequence consisting of SEQ ID NO:
- 4;
- a light chain CDR2 comprising an amino acid sequence consisting of SEQ ID NO:
- 5;
- and a light chain CDR3 comprising an amino acid sequence consisting of SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.