Chimeric antigen receptor system with adaptable receptor specificity
AssigneeCentury Therapeutics, Inc.
InventorsJill Marinari Carton, Michael Francis Naso, Luis Ghira Borges, John Wheeler, Andrew Devaney
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Abstract
The present disclosure provides chimeric antigen receptors (CARs), particularly CARs that have adaptable receptor specificity (arCARs). Also provided are polypeptides of the CARs and other related molecules, polynucleotides, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a disease in a subject are also provided.
Claims13
A universal chimeric antigen receptor system having an adaptable receptor specificity component (arCAR), comprising
- (i) an immune effector cell having a chimeric antigen receptor comprising a first polypeptide comprising:
- (a) an extracellular tag-binding domain,
- (b) a transmembrane domain, and
- (c) at least one intracellular signaling domain;
- and
- (ii) a second soluble polypeptide comprising:
- (a) an antigen-binding domain that binds to at least one antigen on a target cell, and
- (b) a tag that is recognized by the extracellular tag-binding domain;
- wherein:
- the tag comprises the polypeptide sequence of SEQ ID NO:
- 112, and the extracellular tag-binding domain comprises the polypeptide sequence of SEQ ID NO:
- 129;
- or
- the tag comprises the polypeptide sequence of SEQ ID NO:
- 129, and the extracellular tag-binding domain comprises the polypeptide sequence of SEQ ID NO:
- 112.
Dependencies are inferred from the claim text.