T-cells modified to overexpress PHF19
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsYun Ji, Luca Gattinoni
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Abstract
Provided is a mammalian T cell modified to express the Phf19 at a level that is higher than the level of Phf19 expressed by a T cell that has not been modified to express Phf19. Provided is a genetically-modified mammalian T cell comprising a genetic expression vector comprising (a) virally-, bacterially-, or both virally- and bacterially-derived genetic sequences and (b) a genetic sequence encoding Phf19, whereby the genetic sequence encoding Phf19 within the vector is expressed within the T cell. Pharmaceutical compositions, methods of treating a disease, and methods of inhibiting the differentiation of T cells by epigenetic reprogramming are also provided.
Claims17
A mammalian T cell, comprising an antigen-specific receptor, wherein the antigen-specific receptor is a T cell receptor (TCR) or a chimeric antigen receptor (CAR), wherein the T cell comprises a genetic expression vector comprising a genetic sequence encoding Phf19.
Dependencies are inferred from the claim text.