Metformin compositions and methods for treatment of diabetes
OwnerWilliam H. Cross, IIIinventor
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Abstract
The invention provides compositions and methods to treat diabetes with improved formulations in which metformin is combined with at least three antioxidants that contain a stabilizing heteroatom adjacent to a saturated carbon and which help maintain a balance between antioxidant and pro-oxidant properties. The antioxidants include at least the combination of taurine, citrulline and methylcobalamin, and optionally include melatonin. The composition provides management of blood glucose levels comparable to metformin in the same dose without antioxidants, without the phenomenon of undermining metformin performance that is commonly observed in the presence of co-administered antioxidants.
Claims20
A composition for treatment of diabetes comprising a pharmaceutically effective amount of metformin and
- (a) taurine;
- (b) citrulline;
- (c) methylcobalamin;
- and
- (d) beta-alanine.
A composition for treatment of diabetes comprising a pharmaceutically effective amount of metformin and
- (a) taurine in an amount from 50 mg to 200 mg;
- (b) citrulline in an amount from 25 mg to 100 mg;
- and
- (c) methylcobalamin in an amount from 40 μg to 440 μg.
Dependencies are inferred from the claim text.