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US 11,883,423 B2Granted
Nucleobase analogue derivatives and their applications
AssigneeBoard of Regents, The University of Texas System
InventorsZhengrong Cui, Dharmika Lansakara-P.
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Abstract
Disclosed herein are derivatives of nucleobase analogues. The disclosed compounds have a nucleobase moiety and an omega-3 polyunsaturated fatty acid moiety, including pharmaceutically acceptable salt or prodrug thereof. Methods of using these compounds for the treatment of cancers such as pancreatic cancer are also disclosed.
Claims20
A composition comprising a mixture of compounds having Formula II:
- wherein
- R1 comprises an omega-3 polyunsaturated fatty acid having a formula of CH3—CH2—CH═CH—Z—C(O)—;
- and
- Z is a C3-C40 alkenyl group comprising at least one double bond;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.