Glycan therapeutic compositions and related methods thereof

A method for reducing inflammation of a gastrointestinal inflammatory disease in a subject having an immune imbalance, comprising administering to the subject an effective amount of a composition comprising a glycan therapeutic preparation, wherein:

• i) the glycan therapeutic preparation comprises branched glycans comprising glucose, galactose, arabinose, mannose, fructose, xylose, fucose, or rhamnose glycan units;
• ii) the glycan therapeutic preparation comprises an average degree of branching (DB) of at least 0.01;
• iii) at least 50% of the glycans in the glycan therapeutic preparation have a degree of polymerization (DP) of at least 3 and less than 30 glycan units;
• and
• iv) the ratio of alpha- to beta-glycosidic bonds present in the glycans of the glycan therapeutic preparation is between about 1:1 to about 5:1;
• thereby reducing inflammation of the gastrointestinal inflammatory disease in the subject having the immune imbalance.