DNA polymerase gamma inhibitor and uses thereof
AssigneesAcibadem Mehmet Ali Aydinlar Universitesi, Sabanci Universitesi, Koc Universitesi
InventorsMeltem Muftuoglu, Batu Erman, Burak Erman
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Abstract
Pol γ protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol γ. The compounds were shown to directly interact with Pol γ and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.
Claims3
A method of treatment/prevention of cancer cells which are MLH1 mutant/deficient, comprising the step of providing a pharmaceutical composition comprising therapeutically effective amount of a compound having the formula(II):
- and/or pharmaceutically acceptable salts and/or pharmaceutically acceptable solvates in combination with pharmaceutically acceptable diluent, carrier or excipient thereof to a subject in need thereof.
A method of treatment/prevention or delay of MLH1 deficient cancers due to MLH1 promoter methylation, comprising the step of providing a pharmaceutical composition comprising therapeutically effective amount of a compound having the formula(II):
- and/or pharmaceutically acceptable salts and/or pharmaceutically acceptable solvates in combination with pharmaceutically acceptable diluent, carrier or excipient thereof to a subject in need thereof.
A method of treatment/prevention or delay of tumor or cancer cell growth through mitochondrial targeted therapy, comprising the step of providing a pharmaceutical composition comprising therapeutically effective amount of a compound having the formula(II):
- and/or pharmaceutically acceptable salts and/or pharmaceutically acceptable solvates in combination with pharmaceutically acceptable diluent, carrier or excipient thereof to a subject in need thereof.
Dependencies are inferred from the claim text.