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US 11,883,417 B2Granted
Methods and compositions related to glucocorticoid receptor antagonists and breast cancer
AssigneeThe University of Chicago
InventorsDeng Pan, Masha Kocherginsky, Suzanne D. Conzen
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Abstract
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.
Claims20
A method for treating breast cancer in a patient having breast cancer cells, the method comprising:
- a) administering an effective amount of a glucocorticoid receptor antagonist to said patient, wherein said glucocorticoid receptor antagonist is selected from beclometasone, betamethasone, budesonide, ciclesonide, flunisolide, fluticasone, mifepristone, mometasone, triamcinolone, ORG-34517 (Merck), RU-43044, dexamethasone mesylate (Dex-Mes), dexamethasone oxetanone (Dex-Ox), deoxycorticosterone (DOC), CORT 0113083, and CORT 00112716, and wherein the patient expresses a detectable level of glucocorticoid receptor (GR) prior to administration of the GR antagonist;
- b) then administering an effective amount of radiation, immunotherapy, or at least one chemotherapeutic agent.
Dependencies are inferred from the claim text.