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US 11,883,415 B2Granted
High concentration formulation
AssigneeCassiopea S.P.A.
InventorLuigi Maria Longo
Life of this patent
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Abstract
The present disclosure provides high concentration formulations of cortexolone-17α-propionate suitable for treating alopecia.
Claims18
A method of treating androgenetic alopecia, the method comprising topically administering to a subject in need thereof, an effective amount of a pharmaceutical formulation comprising:
- a) cortexolone-17α-propionate at a concentration of about 5 weight percent to about 15 weight percent,
- b) a pharmaceutically acceptable amount of one or more pharmaceutically acceptable solvents, and
- c) less than about 5% water,
- wherein:
- the cortexolone-17α-propionate is fully solubilized in the formulation;
- the formulation has a pH between about 4 and about 5;
- and
- wherein the formulation has a storage stability of at least about 6 months at room temperature as measured by the formulation comprising less than 5 weight percent of cortexolone-21-propionate (17α-hydroxy-21-propionyloxy-pregna-4-ene-3,20-dione) or other degradation products.
5 more elements
Dependencies are inferred from the claim text.