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US 11,883,397 B2Granted
Substituted pyrido[1,2-a]pyrrolo[1,2-d]pyrazines for treating viral infections
AssigneeGilead Sciences, Inc.
InventorsManoj C. Desai, Mingzhe Ji, Haolun Jin, Hyung-Jung Pyun, Teresa Alejandra Trejo Martin
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Abstract
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Claims22
A compound having a Formula (I):
- or a pharmaceutically acceptable salt or stereoisomer thereof,
- wherein:
- L is —C(Ra)2—;
- each Ra is independently hydrogen, halogen, hydroxy, or C1-4alkyl;
- W is a bond;
- X is —CHR2—;
- R2 is hydrogen or Ci1-3alkyl;
- Z is —CHR4—;
- R4 is hydrogen or Ci-1-3alkyl;
- R5 is hydrogen, Ci1-3 alkyl, or Ci1-3haloalkyl;
- Y2 is hydrogen, Ci1-3alkyl, or Ci1-3haloalkyl;
- Y2 is hydrogen, Ci1-3alkyl, or Ci1-3haloalkyl;
- and
- R1 is phenyl, wherein the phenyl is substituted with one, two, or three independently selected halogen substituents.
11 more elements
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.