PqsR inverse agonists

A compound having the formula (I):

• or a pharmacologically acceptable salt thereof,
• wherein
• A represents a group:
• wherein
• said group A is as defined in (i) or (ii):
• (i) A1 is CH;
• A2 is N;
• A3 is N or C—RA3,
• RA3 represents a hydrogen atom, a halogen atom, CF3, CN, C(═O)NH2, C(═O)OH, CH2OH, CH2NH2, OH, OMe, or NH2;
• and
• RA represents CF3, CN, Cl, NO2 or F;
• or
• (ii) A1 is N;
• A2 is N;
• A3 is C—NH2;
• and RA represents CF3, CN, Cl, NO2 or F;
• L is a group represented by formula (L-1) or (L-2):
• wherein
• X1 is NH or S;
• ring B is a partially unsaturated or aromatic, 5-membered heterocyclic ring represented by formula (B-1) or 6-membered heterocyclic ring represented by formula (B-2):
• wherein
• the ring represented by formula (B-1) is:
• (i) a ring, wherein M1 is CH;
• M2 is C or N;
• and each of M3 and M4, independently of one another, is N or NH;
• or
• (ii) a ring, wherein M1 is S;
• M2 is C;
• M3 is N;
• and M4 is CH;
• M11, M12, M13, and M14 each, independently of one another, represents CH or N;
• at least one of M11, M12, M13, and M14 being a group with a heteroatom as defined above;
• U1 and U2 each, independently of one another, represents N or C(R′);
• R1, at each occasion independently, represents a hydrogen atom, a halogen atom, OH, CN, CF3, CH2—OH, OCH3, OCF3;
• or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclo-alkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group;
• each “”, independently of one another, represents a single bond or a double bond, wherein at least one “” in each of the rings of formulae (L-1), (B-1) and (B-2) is a double bond;
• wherein
• X2 is NH, O or S;
• Y1 represents N, NH, S or O;
• Y2 represents N or C(R11);
• Y3 represents N or NH;
• R11 represents a hydrogen atom, a halogen atom, OH, CN, CF3, CH2—OH, OCH3, OCF3;
• or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group;
• each “” independently of one another, represents a single bond or a double bond, wherein at least one “” in the ring of formula (L-2) is a double bond;
• T is R2 or a group:
• —Y—R3, wherein
• R2 is a hydrogen atom, a halogen atom, CN, CF3, CH2—OH;
• NRT1RT2;
• or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group, all of which groups may optionally be substituted;
• RT1 and RT2 each, independently of one another, represents a hydrogen atom or a (C1-C3)alkyl group, which may be substituted by one or more, identical or different, group(s) selected from a halogen atom, OH, ═O, and NH2;
• Y is —O— or —S—;
• and
• R3 is a hydrogen atom;
• or an alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocyclo-alkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group, all of which groups may optionally be substituted.