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AssigneesOhio State Innovation Foundation, North Carolina State University
InventorsJohn Gunn, Laura Kuo, Christian Melander, William M. Huggins
Estimating the term…
In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
A method for inhibiting biofilm formation or dispersing a biofilm in a subject, wherein the subject has a Salmonella enterica infection, comprising the step of administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a compound having a structure represented by a formula:
A method for treatment of a Salmonella enterica clinical condition, comprising administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of a compound having a structure represented by a formula:
Dependencies are inferred from the claim text.