9-flouro-dibenzo[B,G]indeno[1′, 2′:3,4]fluoreno-[1,2-D]oxonine-5, 11, 16,21-tetraone as an antimicrobial agent
AssigneeKing Faisal University
InventorsHany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed, Anas Alfarsi
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Abstract
A 9-fluoro-dibenzo[b,g]indeno[1′,2′:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound, its synthesis, and its use as an antimicrobial agent.
Claims13
A pharmaceutically acceptable composition comprising a therapeutically effective amount of a 9-fluoro-dibenzo[b,g]indeno[1′,2′:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound and a pharmaceutically acceptable carrier, wherein the 9-fluoro-dibenzo[b,g]indeno[1′,2′:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound has the formula:
A method of treating a microbial infection in a patient comprising administering to a patient in need thereof a therapeutically effective amount of a 9-fluoro-dibenzo[b,g]indeno[1′,2′:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound having the formula I:
A method of making a 9-fluoro-dibenzo[b,g]indeno[1′,2′:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound having the formula I:
- the method comprising:
- preparing a reaction mixture of indandione and of p-fluorosalicylaldehyde in a presence of 3-aminopropane-1,2-diol or 1,3-diaminopropan-2-ol in ethanol;
- refluxing the reaction mixture;
- evaporating excess solvent from the reaction mixture under vacuum to obtain a solid;
- and
- recrystallizing the obtained solid from acetic acid to obtain the 9-fluoro-dibenzo[b,g]indeno[1′,2′:3,4]fluoreno-[1,2-d]oxonine-5,11,16,21-tetraone compound.
Dependencies are inferred from the claim text.