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US 11,883,371 B2Granted
Stress test and treatment of chronic kidney disease
AssigneeRenibus Therapeutics, Inc.
InventorsDonald Jeffrey Keyser, Alvaro F. Guillem, Bhupinder Singh, Richard A. Zager
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Abstract
The present invention involves a novel method for treatment of chronic kidney disease comprising administering a compound that induces a stress protein response in a patient, and administering a potent antioxidant if the patent's response is below a predefined level. It also involves a quantitative measure for determining a patient's antioxidant reserve capacity.
Claims9
A method for treating a patient at risk for having suffered kidney injury or kidney disease progression comprising:
- (a) administering a compound to the patient, wherein the compound is a protoporphyrin or mesoporphyrin;
- (b) measuring the response of the patient to the compound, wherein the response comprises increased level of expression of one or more anti-oxidant proteins;
- and
- (c) administering a therapy to the patient if the level of expression of the one or more anti-oxidant proteins is above a predefined level.
1 more element
Dependencies are inferred from the claim text.