Systems and methods for estimating healthy lumen diameter and stenosis quantification in coronary arteries

A system for identifying a lumen diameter of a patient's vasculature, the system comprising:

• a processor configured to perform a method including:
• extracting, for each known healthy vessel segment of a plurality of individuals, one or more lumen features for a plurality of sections of vasculature adjacent to the healthy vessel segment;
• computing a population-based healthy lumen diameter based on the extracted one or more lumen features;
• and
• generating an estimate of fractional flow reserve, generating an estimate or sensitivity of a fractional flow reserve estimate, or generating a model based on the population-based healthy lumen diameter.

A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of identifying a lumen diameter of a patient's vasculature, the method comprising:

• extracting, for each known healthy vessel segment of a plurality of individuals, one or more lumen features for a plurality of sections of vasculature adjacent to the healthy vessel segment;
• computing a population-based healthy lumen diameter based on the extracted one or more lumen features;
• and
• generating an estimate of fractional flow reserve, generating an estimate or sensitivity of a fractional flow reserve estimate, or generating a model based on the population-based healthy lumen diameter.