Skull-mounted drug and pressure sensor

An apparatus comprising:

• an implantable skull-mounted drug and pressure sensor (SOS);
• a metronomic biofeedback pump (MBP) electrically coupled to the SOS;
• a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP,
• where the SOS comprises:
• an optical ventricular catheter comprising a drug delivery port and a CSF optical sensing chamber communicated with the sending and receiving optical fibers included in the drug delivery and communications catheter;
• an LED bundle coupled to the optical ventricular catheter, the LED bundle comprising a plurality of LEDs which are each configured to measure at least one optical absorption profile of cerebrospinal fluid (CSF);
• and
• a photodetector coupled to the optical ventricular catheter,
• where the CSF optical sensing chamber is configured to receive light from the LED bundle and reflect it back to the photodetector, and
• where the MBP includes a drug reservoir, a pump communicated to the drug reservoir, a first pressure sensor coupled to the pump, an optical source and sensor circuit coupled to the sending and receiving optical fibers, and a first microcontroller subsystem for controlling the pump and bidirectionally communicating with the first pressure sensor and pump and the optical source and sensor circuit,
• where the SOS further comprises a second microcontroller subsystem for controlling the LED bundle and photodetector, wherein the second microcontroller subsystem communicates a measurement detected by the photodetector to the first microcontroller subsystem.