System and methods for processing analyte sensor data for sensor calibration

A glucose monitoring system comprising:

• a transcutaneous electrochemical glucose sensor comprising:
• an in vivo portion configured to be inserted into a body of a host, the in vivo portion having at least one electrode and a membrane containing glucose oxidase, and
• an ex vivo portion configured to remain outside of the body of the host;
• a memory storing calibration information for the transcutaneous electrochemical glucose sensor, the calibration information generated by applying a predictive relationship for converting sensitivity information obtained prior to insertion of the transcutaneous electrochemical glucose sensor in the host to a different in vivo sensitivity of the transcutaneous electrochemical glucose sensor;
• and
• a processor programmed to determine an estimated glucose value by applying the in vivo sensitivity of the transcutaneous electrochemical glucose sensor to an in vivo measurement from the in vivo portion of the transcutaneous electrochemical glucose sensor,
• wherein the estimated glucose value is determined without any reference glucose concentration measurements obtained after insertion of the in vivo portion of the transcutaneous electrochemical glucose sensor into the body of the host.

A glucose monitoring system comprising:

• a transcutaneous electrochemical glucose sensor comprising:
• an in vivo portion configured to be inserted into a body of a host, wherein the in vivo portion of the transcutaneous electrochemical glucose sensor comprises an electrode and a membrane comprising glucose oxidase;
• and
• an ex vivo portion configured to remain outside the body of the host;
• a memory storing calibration information for the transcutaneous electrochemical glucose sensor, wherein the stored calibration information is based at least in part on information generated prior to insertion of the in vivo portion of the transcutaneous electrochemical glucose sensor in the host, wherein the stored calibration information is based at least in part on applying a predictive relationship that converts an in vitro sensitivity to glucose to a in vivo sensitivity to glucose, wherein the in vitro sensitivity to glucose is different from the in vivo sensitivity to glucose;
• and
• a processor configured to calibrate data derived at least in part from in vivo measurements generated by the transcutaneous electrochemical glucose sensor after insertion of the in vivo portion of the transcutaneous electrochemical glucose sensor in the host, wherein the processor is configured to perform the calibrating based at least in part on the stored calibration information, and wherein the processor is configured to perform the calibrating without requiring calibration information obtained from a reference glucose measurement after insertion of the transcutaneous electrochemical glucose sensor.

A method of making a glucose monitoring system comprising:

• providing a transcutaneous electrochemical glucose sensor comprising:
• an in vivo portion configured to be inserted into a body of a host;
• and
• an ex vivo portion configured to remain outside the body of the host, wherein the in vivo portion of the transcutaneous electrochemical glucose sensor comprises an electrode and a membrane comprising glucose oxidase, and wherein the transcutaneous electrochemical glucose sensor is associated with an in vitro sensitivity to glucose;
• applying a predictive relationship to the in vitro sensitivity to glucose to generate an in vivo sensitivity to glucose that is different from the in vitro sensitivity to glucose;
• and
• providing a processor configured to calibrate data derived at least in part from in vivo measurements generated by the transcutaneous electrochemical glucose sensor after insertion of the in vivo portion of the transcutaneous electrochemical glucose sensor in the host, wherein the processor is configured to perform the calibrating based at least in part on the in vivo sensitivity to glucose generated by applying the predictive relationship, and wherein the processor is configured to perform the calibrating without requiring calibration information obtained from a reference glucose measurement after insertion of the transcutaneous electrochemical glucose sensor.