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US 11,883,126 B2Granted
Transcutaneous analyte sensors and monitors, calibration thereof, and associated methods
AssigneeDexCom, Inc.
InventorsArturo Garcia, Peter C Simpson, Apurv U Kamath, Naresh C. Bhavaraju, Stephen J. Vanslyke
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Abstract
Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.
Claims20
A method of compensating for drift in an analyte concentration sensor within a biological system using only a signal from an analyte concentration sensor, comprising:
- measuring analyte concentration values using an indwelling analyte concentration sensor to obtain an indwelling analyte concentration sensor reading;
- determining a first slow-moving average of the measured analyte concentration values of the analyte over a first period of time, and basing a first apparent sensitivity of the indwelling analyte concentration sensor based at least in part on the first slow-moving average;
- following the first determining, determining a second slow-moving average of the measured analyte concentration values of the analyte over a second period of time, and basing a second apparent sensitivity of the indwelling analyte concentration sensor based at least in part on the second slow moving average;
- and
- adjusting an actual sensitivity of the indwelling analyte concentration sensor to an adjusted value based on a difference between the first apparent sensitivity and the second apparent sensitivity when the difference between the first apparent sensitivity and the second apparent sensitivity meets a predetermined criteria, wherein the predetermined criteria is based on a range of acceptable sensitivity changes with respect to time.
2 more elements
An analyte sensor system comprising:
- an analyte concentration sensor;
- a monitoring device, wherein the monitoring device is configured to detect when an analyte concentration value as measured by the analyte concentration sensor indwelling in a biological system;
- and
- a processor, wherein the processor is a component of the monitoring device or of a device or a server operatively coupled to the monitoring device, wherein the processor is being programmed to perform operations comprising:
- measuring analyte concentration values using an indwelling analyte concentration sensor to
- obtain an indwelling analyte concentration sensor reading;
- determining a first slow-moving average of the measured analyte concentration values of the analyte over a first period of time, and basing a first apparent sensitivity of the indwelling analyte concentration sensor based at least in part on the first slow-moving average;
- following the first determining, determining a second slow-moving average of the measured analyte concentration values of the analyte over a second period of time, and basing a second apparent sensitivity of the indwelling analyte concentration sensor based at least in part on the second slow moving average;
- and
- adjusting an actual sensitivity of the indwelling analyte concentration sensor to an adjusted value based on a difference between the first apparent sensitivity and the second apparent sensitivity when the difference between the first apparent sensitivity and the second apparent sensitivity meets a predetermined criteria, wherein the predetermined criteria is based on a range of acceptable sensitivity changes with respect to time.
7 more elements
A processor for an analyte system, the processor being programmed to perform operations comprising:
- measuring analyte concentration values from an indwelling analyte concentration sensor to obtain an indwelling analyte concentration sensor reading;
- determining a first slow-moving average of the measured analyte concentration values of the analyte over a first period of time, and basing a first apparent sensitivity of the indwelling analyte concentration sensor based at least in part on the first slow-moving average;
- following the first determining, determining a second slow-moving average of the measured analyte concentration values of the analyte over a second period of time, and basing a second apparent sensitivity of the indwelling analyte concentration sensor based at least in part on the second slow moving average;
- and
- adjusting an actual sensitivity of the indwelling analyte concentration sensor to an adjusted value based on a difference between the first apparent sensitivity and the second apparent sensitivity when the difference between the first apparent sensitivity and the second apparent sensitivity meets a predetermined criteria, wherein the predetermined criteria is based on a range of acceptable sensitivity changes with respect to time.
2 more elements
Dependencies are inferred from the claim text.