Recombinant antibody and uses thereof
AssigneeAcademia Sinica
InventorsShang-Te Danny Hsu, Hui-Wen Chang, Chia-Yu Chang
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Abstract
Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.
Claims8
A recombinant antibody comprising a light chain variable (VL) domain and a heavy chain variable (VH) domain, wherein the VL domain comprises a first light chain complementarity determining region (CDR-L1), a second light chain CDR (CDR-L2) and a third light chain CDR (CDR-L3), and the VH domain comprises a first heavy chain CDR (CDR-H1), a second heavy chain CDR (CDR-H2) and a third heavy chain CDR (CDR-H3), wherein
- the CDR-L1, CDR-L2 and CDR-L3 respectively comprise the amino acid sequences of ENVGTY (SEQ ID NO:
- 1), GTF, and GQSYNYPFT (SEQ ID NO:
- 2);
- and
- the CDR-H1, CDR-H2 and CDR-H3 respectively comprise the amino acid sequences of GYTFTNYM (SEQ ID NO:
- 3), INPSTGYT (SEQ ID NO:
- 4), and ATSTLITGDY (SEQ ID NO:
- 5).
Dependencies are inferred from the claim text.